2/7/2024 0 Comments Wbc normal range femaleWhere there were multiple pregnancies in the study period, only the first was included. Potential participants were identified by searching electronic records for women who delivered live, singleton babies at the John Radcliffe Hospital or midwife-led units in Oxford between 1 st January 2016 and 20 th February 2021, who had a full blood count taken at least once in pregnancy. We performed a retrospective, longitudinal study of 24,318 pregnant women in Oxford, UK, using data collected as part of routine antenatal care. Secondly, we investigated the trajectory of WBC in the first four weeks after delivery, to evaluate how these results should be interpreted in the immediate postpartum period, since this is when infection is commonly suspected, investigated and treated. The primary objective of this study was to define pregnancy specific RIs for total WBC and its constituent cell subtypes (neutrophils, lymphocytes, eosinophils, basophils, and monocytes), and to evaluate whether key characteristics (gestational age, maternal BMI, and ethnicity) affect these limits, using the largest cohort of women to date. This prompted us to consider how we should use WBC to improve the safety of pregnant women and their babies. Importantly, using this pregnancy-specific threshold significantly increases the diagnostic accuracy for infections in pregnancy. Ĭ-reactive protein, another commonly used inflammatory marker, is also elevated in pregnancy, with an upper reference limit almost three times higher than the non-pregnant standard. ![]() However, the upper limit of the reference interval (RI) in pregnancy has been variably reported between 13.8-19.6×10 9/L in previous studies, but all have reported on much smaller populations, with wide variation in ethnicity and gestational age at the time of sampling, ,,. It is reported that the total WBC count is elevated in pregnancy, and even further during labour and the puerperium, so the non-pregnant reference interval (RI) is not reliable in the context of the known, marked changes in maternal physiology. White blood cells (WBC) are commonly measured in pregnancy to investigate infection or inflammation, and most are requested and interpreted by clinicians (of all specialties) in emergency departments, general practice, and hospital outpatient settings. Infections are responsible for more than half of maternal deaths worldwide, so it is essential that clinicians know how to interpret investigations for suspected infection in pregnant women.
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